Significance of polyene antibiotics in increasing of membrane permeability and in treatment animal and plant infection
DOI:
https://doi.org/10.32347/2411-4049.2026.1.69-78Keywords:
polyene antibiotics, dimethyl sulfoxide, amphotericin B, levorin, lipid membranes, membrane permeability, animal and plant infectionAbstract
It is shown that using polyene antibiotics (PA) in combination with dimethyl sulfoxide sharply increase ionic permeability membranes and biological activity of antibiotics. The comparative physical and chemical characteristics of dimethyl sulfoxide and PA is consideration. The effects of a complex interaction and PA examined by the bilayer lipid membranes (BLM). By the method of determine the parameters biological activity of PA it was show that off all the most studied PA promises more effective were amphotericin B and levorin. Results are started according to BLM conduction of cholesterol in the membranes. On the basis of PA developed an ecological model of environmental protection by establishing membrane–active concentration of PA against viral, fungal and bacterial infection for animals and plants. Using polyene antibiotics (PAs) in combination with dimethyl sulfoxide (DMSO) was shown to increase ion permeability of membranes and biological activity of antibiotics sharply. The comparative physical and chemical characteristics of dimethyl sulfoxide and PAs were determined. The effects of a complex relation between PAs and the bilayer lipid membranes (BLM) were studied. The parameters of biological activity of PAs and BLM were determined. It was shown that among all the studied PAs, amphotericin B and levorin were the most effective. Ion permeability of BLM was shown to depend on the concentrations of amphotericin B, levorin and cholesterol. On the basis of PAs, biological active preparations were developed against viral, bacterial and fungal diseases. It has been shown that the used preparation can completely prevent the growth of the Tobacco mosaic virus. It should be especially noted that after treatment with the “Infanvir” preparation the infected plants are not only cured but also regenerated in full. Moreover, the vegetable plants treated with such preparation had 2 times more harvest than the reference ones. It is supposed that the antivirus and antifungal effect of the “Infanvir” preparation is related to their interaction with lipid components of cytoplasmic membranes, causing destruction of the structure of pathogenic microorganism cells.
References
Borowski E. Novel approaches in the rational design of antifungal agents of low toxicity (2000) Farmaco, v. 55, p. 206-208.
Aszalos A, Bax A, Burlinson N., Roller P, McNeal C (1985) Physico-chemical and microbiological comparison of nystatin, amphotericin A and amphotericin B, and structure of amphotericin A. J Antibiot (Tokyo) 38: 1699-1713.
Baginski M., Czub J. (2009) Amphotericin B and Its New Derivatives - Mode of Action. Current Drug Metabolism, v. 10, pp. 459-469.
Ciesielski F, Griffin DC, Loraine J, Rittig M, Delves-Broughton J, Bonev BB (2016) Recognition of membrane sterols by polyene antibiotics amphotericin B and natamycin, A 13C MAS NMR study. Frontiers in Cell and Developmental Biology l4, Article 57: 1-12.
Cohen BE (2010) Amphotericin B Membrane Action: role for two types of ion channels in eliciting cell survival and lethal effects. J Membrane Biol 238: 1–20.
De Marie S, Janknegt R, Bakker-Woudenberg IАJ (1994) Clinical use of liposomal and lipid-complexed amphotericin В. J Antimicrob Chemother 33: 907-916.
Vafa Kh. Qasimova, Gulnara H. Sultanova, Arifa A. Samedova, Tahmina P. Tagi-zade, Turkan J. Pashazade, Khalil M. Кasumov. 2018. Development of the Method to Enhancing the Biological Activity of Polyene Antibiotics and its Use for Environmental Improvement. J. Chemical Ecology, Elsever publishing (in press). 8. Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD (2012) Amphotericin primarily kills yeast by simply binding ergosterol. Proc Natl Acad Sci USA 109: 2234-2239.
Ibragimova VKh, Aliev DI, Alieva IN (2002) Biophysical and medicobiological aspects of application of polyene antibiotics in combination with dimethyl sulfoxide. Biophysics 47: 774-781.
Ibragimova V, Alieva I, Kasumov Kh, Khutorsky V (2006) Transient permeability induced by alkyl derivatives of amphotericin B in lipid membranes. Biochim Biophys Acta 1758: 29-37.
Ibragimova VKh, Samedova AA, Sultanova GG, Gasimov KhM (2014) The antiviral and antifungal action of INFANVIR antibiotic at the vegetable crops. The First European Conference on Biology. Section 2. Physico-chemical Biology and Medical Sciences, Austria, Vienna: 45-50.
Kasumov KhM (2009) Structure and membrane function of polyene macrolide antibiotics. Monograph, Moscow «Nauka»: 1-512.
Mamidi A, DeSimone JA, Pomerantz RJ (2002). Central nervous system infections in individuals with HIV-1 infection. J Neurovirol 8: 158-167. 14. Récamier KS, Hernández-Gómez A, González-Damián J, Ortega-Blake I (2010) Effect of membrane structure on the action of polyenes: I. Nystatin action in cholesterol- and ergosterol-containing membranes. Journal of Membrane Biology 237: 31-40.
Samedova АА, Tagi-zade TP, Кasumov KhМ (2018) Dependence of ion channel properties formed by polyene antibiotics molecules on the lactone ring structure. J Bioorganic Chemistry, 2018, Vol. 44, No. 3, pp. 337–345.
Sepkowitz KA (2002) Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome. Clin Infect Dis 34: 1098-1107.
Vaisman II, Berkowitz ML (1992). Local structural order and molecular associations in water-DMSO mixtures. Molecular dynamics study. Am Chem Soc 114: 7889-7896.
Yu Z, Quinn P (1994) Dimethyl sulphoxide: a review of its applications in cell biology. Bioscience Reports 14: 259-281.
Zotchev S.B. Biosynthesis of natural products applied to drug discovery. Curr. Top. Med. Chem., 2008, v. 8, pp. 616-617.
Qasimova V.Kh., Sultanova G.G., Baghirova A.A., Tagizade T.P., Pasha-zade T.J., Kasumov Kh.M. 2018. Development of the method to Enchancing of Biological Activity of Polyene Antibiotics and its Use in Environmental Improvement. J. Chemical Ecology (in press).
Lewis J., Papavizas J. Biological control of plant diseases. Soil Biology Biochem., 1987, v. 191(2), p. 114.
Guliyeva E.A., Jalaladdinov F.F., Asgerova T.Y., Haqverdiyeva T.M. (2022) Synthesis of Cu (II), Ni (II), Co (II) complexes with hydrazide of maleic acid. İnternational scientific and practical conference “Cutting EDGE-Science“. Shawnee, USA. pp. 82-84. DOI:10.5281/zenodo.509167
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